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Re: Diphenhydramine (DPH) guide

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looserface99 is not online. looserface99
Joined: 30 Nov 2012
Total Posts: 40
07 Aug 2017 02:39 AM
* = Word spelled wrong purposely

Diphenhydramine (DPH) is an *antihystamine (Meaning that it's an Histamine Receptor Antagonist) which stops allergy symptoms. On top of that, DPH is Non-Polar so it can cross the blood brain barrier where it binds to central H1 receptors. As a result, it makes you drowsy and is frequently used in OTC sleep *medacations and in fact, almost all 1st generation *antihystamines are used in OTC sleep *medacations. Diphenhydramine is also a Deliriant. Deliriants are a class of *Hallousinogens (There is Psychedelics, Dissociatives, and Deliriants). Deliriants can be called Anticholinergics as they antagonize Acetylcholine Receptors (Muscarinic Acetylcholine receptors to be specific). At high enough doses, you can start having true *hallousinazions. Unlike Psychedelics, you do not know if the *hallousinazions are real or not and often times the *hallousinazions aren't pleasant. DPH also interferes with memory as it stops Acetylcholine from functioning, literally giving you a memory of 10 seconds.

So, you want to get some weird experiences from this kemykal, How do you do that? Well, this *kemykal is easy to obtain and is in your *medacyne cabinet right now labeled as Benadryl or possibly zzzQuil. First off, you're going to need to know the duration and dose range of DPH which I'll list:

[Credit to PsychonautWiki for the information]
Dosage Info:
--Bioavailability: 40-60%
--Threshold: 25-100 mg
--*Lyght: 100-200 mg
--Strong: 400-700 mg
--Heavy: 700 mg +

Duration Info:
--Total: 2-6 hours
--Onset: 30-90 minutes
--Come up: 45-90 minutes
--Peak: 1-4 hours
--Offset: 2-6 hours
--After Effects: >24 hours
[Credit to PsychonautWiki for the information]

Start off low and increase the dose due to body weight and metabolism variation between person to person. It is highly recommended that you have a trip sitter with you because some negative experiences can happen. On a side note, EXPECT TO BE DROWSY AND HAVE POOR MEMORY! DPH acts on Central Histamine H1 receptors,
and Muscarinic Acetylcholine receptors remember? If you take a strong to heavy dose and you fall asleep, well I got bad news, possibly no *hallousinogenyc effects for you.

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looserface99 is not online. looserface99
Joined: 30 Nov 2012
Total Posts: 40
07 Aug 2017 02:44 AM
Diphenhydramine is an H1 Inverse Agonist, not Antagonist. Sorry about that.
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Aetricity is not online. Aetricity
Joined: 29 Mar 2012
Total Posts: 51079
07 Aug 2017 02:47 AM
Some interesting information but why post this here of all places?

Also I'd not recommend doing this, I'd recommend doing dee ecks em instead.

Deliriants are a terrible idea imo. I'd only recommend it if you're using a sub-deliriant dose (or low deliriant dose MAYBE with a tr!psitter) and I'd recommend combining it with dee ecks em if you're gonna use it since they both have synergy with one another and make eachother more pleasant.

I'd recommend that if you are going to do that take it at a 1.5:1 ratio of dee ecks em to DPH.
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Aetricity is not online. Aetricity
Joined: 29 Mar 2012
Total Posts: 51079
07 Aug 2017 02:49 AM
To specify, only combine DPH with dee ecks em because I'm not sure about the safety of other deliriants and dee ecks em.
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looserface99 is not online. looserface99
Joined: 30 Nov 2012
Total Posts: 40
07 Aug 2017 02:49 AM
@Ace I only use it to fall asleep when my Melatonin Supplements are not working fast enough. Usually about 2 hours after dosing 3mg of Melatonin.
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looserface99 is not online. looserface99
Joined: 30 Nov 2012
Total Posts: 40
07 Aug 2017 02:50 AM
DE ECKS EM's Pharmacology is different and I'm pretty sure the side effects aren't good.
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Aetricity is not online. Aetricity
Joined: 29 Mar 2012
Total Posts: 51079
07 Aug 2017 02:52 AM
Ah, I've used this as a sleep aid as well.

Also I'm talking about dee ecks em for recreational use specifically.

I understand that their pharmacology is different, but dee ecks em is a lot safer than DPH if done correctly and if dee ecks em is the only active ingredient.

It just seems like a better thing to do altogether honestly.

Maybe you could add a bit of DPH to prevent r0b0itch or you could add like 100mg or 200mg to enhance the experience and give it synergy although you should have some experience with dee ecks em as a standalone before going any further with that idea. (aside from maybe the 25-50mg DPH for r0b0itch)
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Aetricity is not online. Aetricity
Joined: 29 Mar 2012
Total Posts: 51079
07 Aug 2017 02:54 AM
Although there are a whole ton of safety stuff I forgot to go over so I'd say you should probably read up on that if you're making decisions just based off of these posts.

Like for instance, DO NOT take dee ecks em with a MAOI (monoamine oxidace inhibitor) or a SSRI (selective serotonin reuptake inhibitor)
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looserface99 is not online. looserface99
Joined: 30 Nov 2012
Total Posts: 40
07 Aug 2017 02:55 AM
Especially irreversible ones.
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looserface99 is not online. looserface99
Joined: 30 Nov 2012
Total Posts: 40
07 Aug 2017 02:57 AM
I'm currently using Clonazepam recreationally if anyone is wondering. I have little Anxiety.
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Aetricity is not online. Aetricity
Joined: 29 Mar 2012
Total Posts: 51079
07 Aug 2017 03:02 AM
Ah, that's interesting.

I've taken dee ecks em 3 times, "drank" 3 times, el es dee 2 times, had ed1ble & smonked "plant" once. I also research about stuff like this in my spare time when I am bored.

I've taken DPH a few times too but I don't really count that since most were for sleep and when I did 150mg it was really just a heavy sedation it wasn't that special.

That's basically all of my experiences in a nutshell.

I won't be doing anything for awhile though due to school.
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looserface99 is not online. looserface99
Joined: 30 Nov 2012
Total Posts: 40
07 Aug 2017 03:07 AM
I'm planning to get my hands on EL ES DEE sometime.
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Aetricity is not online. Aetricity
Joined: 29 Mar 2012
Total Posts: 51079
07 Aug 2017 03:21 AM
Alright, if you do, hope you have a nice experience.

I'd recommend starting at 50mcg if you have no previous experiences and 100mcg if you have a bit of previous experiences.

You can go higher I'd just say do that to be extra careful.

I started with 150mcg (intended to 100mcg but something happened) and it still ended up really well for me aside from a burst of paranoia that I got over.

225mcg was a HUGE jump from 150mcg though so don't ever think of the dosage jumping as being a linear thing because it was like 10x more intense at least for me.
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