dssdd253
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| Joined: 29 Jun 2012 |
| Total Posts: 4452 |
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| 03 Apr 2017 10:32 PM |
| WAS MURDERED BY FACTIONS IN HIS OWN GOVERNMENT. |
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dssdd253
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| Joined: 29 Jun 2012 |
| Total Posts: 4452 |
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dssdd253
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| Joined: 29 Jun 2012 |
| Total Posts: 4452 |
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| 03 Apr 2017 10:37 PM |
The circadian clock allows an organism to anticipate daily changes imposed by the environment. The response to LPS is altered depending on time of day; however, the molecular mechanisms underlying this are unclear. We find that the clock in myeloid cells plays a role in LPS-induced sepsis by altering NF-κB activity and the induction of the microRNA miR-155. LPS causes the repression of BMAL1 via the targeting of miR-155 to two seed sequences in the 3′-untranslated region of Bmal1. Lack of miR-155 has profound effects on circadian function and circadian induction of cytokines by LPS. Thus, the molecular clock is using miR-155 as an important regulatory component to control inflammation variably across the circadian day in myeloid cells.
BUmp |
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| 03 Apr 2017 10:38 PM |
lets hope the 45th is too
OOO ZINGA! |
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