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Re: THE 35TH PRESIDENT OF THE REPUBLIC

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dssdd253 is online. dssdd253
Joined: 29 Jun 2012
Total Posts: 4452
03 Apr 2017 10:32 PM
WAS MURDERED BY FACTIONS IN HIS OWN GOVERNMENT.
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dssdd253 is online. dssdd253
Joined: 29 Jun 2012
Total Posts: 4452
03 Apr 2017 10:37 PM
bump
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dssdd253 is online. dssdd253
Joined: 29 Jun 2012
Total Posts: 4452
03 Apr 2017 10:37 PM
The circadian clock allows an organism to anticipate daily changes imposed by the environment. The response to LPS is altered depending on time of day; however, the molecular mechanisms underlying this are unclear. We find that the clock in myeloid cells plays a role in LPS-induced sepsis by altering NF-κB activity and the induction of the microRNA miR-155. LPS causes the repression of BMAL1 via the targeting of miR-155 to two seed sequences in the 3′-untranslated region of Bmal1. Lack of miR-155 has profound effects on circadian function and circadian induction of cytokines by LPS. Thus, the molecular clock is using miR-155 as an important regulatory component to control inflammation variably across the circadian day in myeloid cells.


BUmp
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MsMiaWallace is not online. MsMiaWallace
Joined: 05 Nov 2016
Total Posts: 1778
03 Apr 2017 10:38 PM
lets hope the 45th is too

OOO ZINGA!
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